Infectious disease is a major health concern worldwide. The development of drug resistance is a growing threat and has created a great demand for the development of novel therapeutics to fight infectious disease. Researchers at the University Nebraska Medical Center, in conjunction with researchers at San Diego State University, have identified a novel immune stimulating peptide called EP67. EP67 is a conformationally-biased, response selective agonist of the human C5a. EP67 has been modified to enhance its immune stimulating properties while eliminating unwanted inflammatory stimulating properties. Originally EP67 was designed to be a vaccine adjuvant, but recently UNMC and SDSU researcher have discovered that EP67 can be used on its own to treat a variety of microbial infections. EP67 has been tested in vivo and was effective at treating both influenza and S. aureus (MRSA) infections in mice. EP67 is a novel treament option for a variety of infections and could also be used in conjunction with current therapies.