Bock co-polymers containing ionic and nonionic blocks (“block ionomers”) have been utilized to produce a variety of nanomaterials. Charge-driven self-assembly resulted in formation of complexes of nanoscale size referred to as blok-ionomer complexes (BIC). The core of BIC can also incorporate a variety of compounds or even particles including biologically active molecules through a combination of electrostatic, hydrophobic, and hydrogen bonding interactions. Such materials are uniquely suited for the delivery of biomacromolecules, as well as ionic and nonionic drugs. Ability to incorporate a variety of therapeutic cargo creates a very broad range of application opportunities for BIC. Technology presents BIC with antioxidative, antiviral, pH-sensitive and other activities.