Anti-inflammatory polymers for IBD

New polymer system directly targets inflammation in the digestive system

  • Orally administered therapy for IBD
  • Targeted to the digestive system
  • apable of packaging and delivering additional drugs

 
Licensing Manager: Matt Boehm, Ph.D.
mboehm@unmc.edu or 402-559-2166
 

Description

New polymer system directly targets inflammation in the digestive system

Researchers at the University of Nebraska have found a way to improve the treatment of inflammatory bowel diseases, Crohn’s disease and ulcerative colitis.
 
The new therapy is based on an improved version of chloroquine, a traditional malaria treatment with potent anti-inflammatory properties. Taking chloroquine systemically for long periods of time can cause negative side effects, including irreversible retina damage and hearing loss. But UNMC’s new chloroquine-based polymers directly target inflammation within the digestive system, harnessing chloroquine’s anti-inflammatory effects while minimizing side effects.
 
The digestive system does not actively absorb the chloroquine-based polymers because they are so large. Instead, the polymers are localized within the digestive tract where they can have a direct effect and maximum impact on inflammatory bowel disease.
 
The chloroquine-based polymers can also be used to package and deliver other drugs to help treat inflammatory bowel disease.
 
Initial animal studies have been conducted demonstrating localization of orally administered chloroquine-based polymers to the digestive tract.
 
To discuss licensing opportunities contact Matt Boehm, Ph.D., at mboehm@unmc.edu or 402-559-2166.
 

Additional Info

Provisional patent application filed