Tissue specific signatures could improve future diagnostics
UNMC researchers have identified a blood-based approach for detecting tissue-specific exosomes.
Exosomes are cellular excretions that are useful as biomarkers and diagnostics because they contain diverse tissue specific cargo, including any products of the cell like fats, proteins, DNAs and RNAs. UNMC researchers have identified tissue specific markers on exosomes that help identify their origin. Exosome markers for brain, heart, kidney, lung, and liver tissues have been identified. These unique signatures help identify tissue-specific biomarkers, and potentially aid in the development of new diagnostics.
Signatures have been validated in animal and human cadaver specimens, and will enable future diagnostic tests.
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