Jak2 conditional knockout mouse

Mouse model developed for the study of tissue-specific JAK2 signaling

  • Research use only
  • Non-exclusive licenses available

 
Licensing Manager: Matt Boehm, Ph.D.
mboehm@unmc.edu or 402-559-2166.
 

Description

Jak2 conditional knockout mouse

JAK-STAT signaling is one of the key signaling pathways involved in different types of cancer and inflammatory diseases. One of the obstacles of studying the pathway is that conventional JAK2 knockout mice are embryonic lethal.
 
Our conditional JAK2 knockout mouse model allows for tissue-specific deletion of JAK2 and subsequent investigation of the importance of JAK2 signaling within the particular tissue(s). The conditional knockout (floxed) allele of JAK2 was generated by placing loxP sites around the first coding exon of Jak2 and the conversion of the floxed allele into a null mutation can be achieved when the mouse is crossed with another strain carrying a tissue specific Cre.
 
The model has been used in Dr. Wagner and his collaborators’ labs to study the direct function of Jak2 in multiple tissues and diseases.
 
This unique Jak2 conditional knockout mouse will be useful in further understanding signaling events dependent upon Jak2 and its downstream effector molecules. This knowledge will ultimately be useful in determining novel drug delivery pathways for multiple disease conditions which use this pathway of cell signal transduction.
 
To discuss licensing opportunities please contact Matt Boehm, Ph.D., at mboehm@unmc.edu or 402-559-2166.