Nanofiber formulation provides versatile approach to treating bone defects
Researchers at the University of Nebraska Medical Center have developed a nanofiber-based therapy for the treatment of bone defects.
This therapy consists of mineralized short nanofiber fragments that are conjugated to BMP-2 mimicking peptides. These short nanofiber fragments are easy to manufacture and can be made from a variety of polymers. They are versatile and can be formulated into powders, gels, and sprays for easy administration.
These short nanofibers have performed exceptionally well in repairing periodontal injuries in rats following molar tooth extraction.
Additionally, the short nanofibers can be used as a platform technology for delivering other therapeutic agents instead of BMP-2. Work is being done to develop short nanofiber formulations for treating hemorrhage and soft tissue injuries.
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