NF-κB Pathway Inhibitor

New compounds to treat cancer

  • Inhibits the NF-κB pathway
  • Causes degradation of IKKβ and IKKα
  • Nanomolar potency in cell-based studies

Licensing manager: Matt Boehm, PhD or 402-536-9881

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UNMC scientists invent new compounds to treat cancer

Amarnath Natarajan

Amarnath Natarajan, PhD

Researchers at the University of Nebraska Medical Center created a molecule capable of specifically inhibiting the NF-κB pathway, a key target involved in a variety of cancers and other diseases.
The NF-κB pathway is often overactive in a number of cancers. Therefore, new ways to shut off this pathway could yield important new cancer treatments.
Amarnath Natarajan, PhD, and his team developed a small molecule called 36-252 that destroys key members of the NF-κB pathway—specifically the proteins IKKβ and IKKα. In ovarian cancer cell studies, 36-252 effectively inhibited cell growth at nanomolar concentrations, stimulated cell death (apoptosis), and effectively inhibited NF-κB activity. 36-252 was also effective at destroying ovarian cancer stem-like cells.
UNeMed is interested in forming collaborations with industry to further explore the potential of 36-252 as a novel therapy of the treatment of cancer and other diseases associated with overactive NF-κB.
To discuss licensing opportunities please contact Matt Boehm, PhD, at or 402-536-9881.

Additional Information

Provisional patent application filed.